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In obese patients undergoing bariatric surgery, a single, low dose of KET (0.5 mg/kg) at induction of anesthesia determined a very fast (hours) amelioration of post-operative depression and pain and an opioid-sparing effect

For example, a multicenter prospective cohort study involving 39 patients with AP found that those receiving vitamin E supplementation (400800 IU/day) showed a significant reduction in serum levels of inflammatory markers such as CRP and IL-6 within five days of treatment

Chem Biol Interact 174:2737