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Main clinical impact of these technologies is an early identification of subclinical neuropathy that allows prompt implementation of intensive glycemic control, lifestyle interventions and neuroprotective therapies, which in turn has been shown to slow DPN progression and reduce incidence of foot ulcers and falls

Along with mitochondria, synapses are considered end effectors of many molecular mechanisms related to ASD, and the convergence of different neurodevelopmental pathological mechanisms on synapses can at least partially explain the behavioral similarities in different individuals on the spectrum