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Very low calorie diets (below 800 calories daily) should only be done under direct medical supervision with appropriate supplementation and monitoring

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Data from preclinical models in mice and human data also suggest that the tolerability and efficacy of GLP-1 agonists vary with the hormonal cycle and that higher circulating estrogen levels are associated with a heightened risk of nausea and vomiting

Likewise, there were no significant correlations between the non-fasting metabolic hormones and the GI symptoms measured on the VAS-scale and total IBS-SSS in POTS (Supplementary Table S12)