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A meta-analysis of 16 clinical trials (N=6,276) did not find a significant effect of vitamin supplementation on depressive symptoms.38 However, a review of five clinical trials (N=6,507) by da Silva and colleagues found that supplementation with folic acid, vitamin B6, and vitamin B12 was effective in preventing depression in patients recovering from stroke.39 Supplementation with folic acid, vitamin B6, and vitamin B12 may improve symptoms of depression and bipolar disorder among patients with these disorders by increasing the absorption and utilization of mood-stabilizing medications.35 Hyperhomocysteinemia is also associated with an increased risk of schizophrenia

Without adequate Se, there is an imbalance between the activation and inactivation of thyroid hormones [47]

Mammalian olfactory receptors