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In their study, human endothelial cells treated with HTY and sulphate metabolites showed reduced reactive oxygen species (ROS) generation and downregulation of adhesion-related genes such as ICAM1, VCAM1, and E-selectin genes [74]

Her urine-organic acid analysis indicated an increase in 5-oxoproline levels, although the difference was not statistically significant compared with that of previously observed values

Stambolija V, Stambolija TP, Holjevac JK, Murselovic T, Radonic J, Duzel V, et al