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For more on the weekly dosing cadence after reconstitution, see our semaglutide dosing schedule guide

It may occasionally be accessed as an unlicensed special-order import through private prescriptions, but it is not part of standard UK formularies

Adding a teaspoon of baking soda to a glass of water can help balance electrolytes

Side Effects of Each Medication Both medications can cause specific side effects, and understanding these side effects can help you make an informed decision: Common Side Effects for Both Nausea (most common, especially when starting) Vomiting Diarrhea Constipation Stomach pain Fatigue Headache Semaglutide-Specific Side Effects Nausea affects about 44% of users initially Side effects typically improve after 4-8 weeks Injection site reactions are rare Tirzepatide-Specific Side Effects Nausea affects about 12-18% of users (lower than Semaglutide) May cause more digestive upset initially Some patients report better tolerance overall Most side effects are temporary and resolve as your body adjusts to the medication