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In this study, we elucidate the mechanism by which reduced lithocholic acid suppresses glucagon-like peptide 1 via farnesoid X receptor activation under high-temperature and humidity condition

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On the basis of the models characterised above, 10 weeks of once-weekly dosing of IcoSema [175 U (1050 nmol) icodec/0.5 mg semaglutide], icodec [175 U (1050 nmol)] or semaglutide (0.5 mg) was simulated for each participant, using the approach previously described [20], and maximum concentration at steady state ( C max,SS ) was derived for icodec and semaglutide as applicable

1214 Higher intravenous doses of ALA 1200 mg/d were found to have a higher incidence of adverse reactions than either ALA 600 mg/d or placebo