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These metabolic benefits were dose-dependent and correlated with weight loss magnitude

Twelve of these genes (KRT1, CBR1, ALDOB, AHNAK, CSRP1, DHRS7 FABP5, NEFL, CRABP2, CALD1, RIMS1, and ALB) had the most significant expression differences, and then a prognostic model was constructed focusing on 6 genes, with DHRS7 finally determined as the primary gene for subsequent study

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Individuals who are pregnant, breastfeeding, or have a history of pancreatitis, kidney failure, gallbladder disease, medullary thyroid carcinoma, MEN2 syndrome, or eating disorders should not use GLP-1 medications regardless of dose