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Studies of topical use have reported improvements in skin density, thickness, and appearance of fine lines over 12-week windows, with a well-documented safety profile at typical cosmetic concentrations (Borkow, Using Copper to Improve the Well-Being of the Skin, 2015)

Topical formulations, such as creams and lotions, may not absorb and get into the blood in sufficient amount to interact with other medications, although there is very little information on how much of CBD gets into the blood eventually

As an alternative to injection, testosterone cream can be applied externally