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A short non-diabetic cohort measured a flat 2.5 mg dose for about four weeks and found weight and insulin-resistance movement (about -4.7% body weight). That makes "2.5 mg has no data" outdated

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From a pharmacological standpoint, several considerations are relevant: Gastrointestinal effects : Retatrutide, like other GLP-1-based therapies, commonly causes nausea, vomiting, diarrhoea, and reduced appetite