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The inhibitory activity towards DPP1 was improved by introduction of aminobutanoic acid (Abu) in the P2 position, whereas various hydrophobic, aromatic amino acid residues, such as phenylalanine (Phe) and biphenyl (Bip), were evaluated in the P1 position

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Key contraindications: Personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, history of pancreatitis, and pregnancy or plans to become pregnant