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B12 deficiency is far more common than most people realise, and even a mild shortfall can cause significant and debilitating symptoms including persistent fatigue and low energy, brain fog and poor concentration, low mood and irritability, muscle weakness, and tingling or numbness in the hands and feet

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While often used interchangeably, these terms refer to distinct concepts that directly impact experimental accuracy and reproducibility

Translated to a 70 kg human using allometric scaling, that yields approximately 250 to 500 mcg per day