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5 Conclusion Collectively, based on the comprehensive evidence reviewed, this work establishes the bidirectional oral-gut axis as a fundamental mediator of systemic health

Several factors influence the patients level of adherence and can be distinguished as social and economic factors, patient-related factors (health beliefs, health literacy), therapy-related factors (complexity of the treatment, adverse events), presence of comorbidities (neurological/psychiatric or of different origins), and factors related to the healthcare system (doctor-patient relationship, difficulty in obtaining follow-up visits)

Third, the combination of senolytics with other methods for reducing senescence was not examined

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