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However, the well-recognized pleotropic effects of GLP-1R agonists (normalization of neurogenesis and synaptic plasticity, protection against neuronal apoptosis, and suppression of increased oxidative stress), in conjunction with the presence of GLP-1Rs in the hypothalamic nuclei that regulate sleep and wakefulness, suggest several possible direct effects of GLP-1R agonists in affecting sleepiness and other related parameters (memory, anxiety, and depression) [77, 114]

Both are GHRH-receptor agonists that raise endogenous GH and IGF-1, but tesamorelin has far stronger and more recent human data than sermorelin

Caruso I., Cignarelli A., Sorice G.P

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