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Frequently Asked Questions About B12 Depending on your geographic location, B12 shots can range between $15-$100, with most IV Therapy / Longevity locations charging between $25 to $75

Underlying health conditions: Some health conditions, such as gastrointestinal disorders or liver disease, can affect B12 absorption and metabolism, potentially leading to shorter-lasting benefits from B12 injections

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The FDA explains that compounded drugs are not FDA-approved , meaning the agency does not verify their safety, effectiveness, or quality before marketing (see Compounding and the FDA: Questions and Answers )