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When norepinephrine is released in response to cold sensation it binds to -adrenergic receptors on the surface of brown adipocytes triggering the activation of adenylate cyclase

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Calcium influx in response to glutamate puffs at one dendritic location was mediated almost exclusively by mGluRs with negligible contribution of NMDARs, AMPARs, and VGCCs while, at another location on the same cell, calcium responses were mediated by NMDARs, AMPARs, and VGCCs, and sequential blockade of these sources gradually reduced and eventually eliminated calcium responses (Topolnik et al., To summarize, the requirement for [Ca 2+ ] i rise is one common condition for induction of long-term plasticity in inhibitory neurons