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doi: 10.1016/j.enzmictec.2015.02.009 41 LiR.LandfesterK.FergusonC

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Therapeutic targeting of HIF pathways offers the unique opportunity to simultaneously disrupt multiple cancer hallmarks, including abnormal glucose metabolism (e.g., Warburg effect), pathological angiogenesis via VEGF induction, and resistance to apoptosis and immune surveillance (98, 184, 185)

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