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There isn't enough research to say for certain how safe GLP-1 patches are, which is one of the main concerns around them

In this randomised, placebo-controlled trial, adolescents receiving 300 mg/day of LBPs exhibited greater reductions in Hamilton Depression Rating Scale (HAMD) scores and higher remission rates than the placebo group

Basic legitimacy markers are present

Existing addiction treatments face a number of obstacles to adoption that have severely limited their use, including patient resistance, stigma, side effects, low long-term adherence rates, and, for treatments like methadone, massive cultural resistance that has persisted for over 50 years, despite a mountain of evidence showing the public health benefits of expanded access