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2.3 Data screening, extraction, and analysis Title and abstract screening, followed by full-text review, was conducted independently in Covidence by two reviewers (CL, EP) as shown in Figure 1

10.1007/s00424-015-1758-5 85 CuthbertJ

36 Another cause could be a defect in leptin signaling which is related to the suppressor of cytokine signaling 3 (SOCS3) and insulin receptor substrate/phosphatidylinositol 3-kinase (IRS/PI 3-K) signaling pathways