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This therapy depends on methionine being administered within 10 hours of poisoning

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Airway epithelial cells from COPD patients produce intracellular ROS mainly from leaky abnormal mitochondria [28], but also from membrane-bound reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX), from the xanthine/xanthine oxidase system and also from neutrophil-derived myeloperoxidase (MPO) [20]

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