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In 2008, Yang and Stockwell named two small molecules (RSL3 and RSL5) based on a synthetic lethal screening system, which can activate iron-dependent and non-apoptotic cell death in the presence of oncogenic RAS (Yang and Stockwell 2008)

doi: 10.1016/j.neulet.2016.02.011 90 ThakkarHChatterjeeSVermaAChandrasekarNKhairnarAShahRP