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Being a receptor involved in many systems, including reward, feeding, and memory, GHSR1a represents an important target for the treatment of psychiatric and metabolic disorders

In contrast, inhaled anesthetics, such as isoflurane, have been associated (in both in vitro and experimental studies) with the activation of pathways that increase the expression of HIF-1 and HIF-2 and the promotion of anti-apoptotic properties, which may favor the invasion and dissemination of neoplastic cells [94]