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Clinical studies point to reductions of up to 25% in body weight, a figure expected to be exceeded with the new generations of GLP-1 still in trial phase

Treatment with PAS* restored plasma lipopolysaccharide (LPS) levels that were elevated in the HFD mouse model to those observed in mice fed normal chow, indicating an improvement of the gut barrier function

Interestingly, recent pilot studies have reported preliminary evidence of potential benefits of acetylcarnitine supplementation alone or as part of a combined dietary intervention in the treatment of long COVID-associated fatigue, energy metabolism alterations and immune changes [93, 110]

Other investigations indicate that chronic treatment with riluzole, which includes a reduction in glutamatergic neurotransmission among its mechanisms of action, attenuates the spread of tauopathy in rodent models (280)