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Clinical Evidence: Retatrutide's Impressive Results In a recent phase 2 trial for obesity, retatrutide demonstrated remarkable efficacy: Up to 24.2% weight loss at 48 weeks with the highest dose, surpassing the weight loss seen with both semaglutide (15-17%) and tirzepatide (22.5%) at their respective highest doses

GLP-1 side effects GLP-1 medications have a different side effect profile, heavily weighted toward gastrointestinal symptoms: Nausea (the most common, affecting 40-50% initially, but typically improving over weeks) Bloating and abdominal discomfort The key difference is trajectory

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