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121 In an uncontrolled trial in 30 men with infertility, the majority of participants experienced improvement in at least one sperm parameter and pregnancy occurred for six participating couples after taking 2 mg lycopene twice daily for three months

Because participant 12 complained of excessive sweating and salivation 1-3 h after ingestion of the -butyrobetaine supplement , the dosage was reduced to 37.5 mg/(kg body wt-d) for participants 13-16

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This is why it is labelled a conditionally essential nutrient