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Participants were excluded from the study if there was an estimated glomerular filtration rate of greater than 60 mL/min?1.73 m^2 per the MDRD formula

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The emergence of spatial proteomics and 3D ECM mapping 4,5,6 is revealing the 3D structure of the ECM, showing that healthy and diseased tissue share ECM components, but their amount, distribution, density, and articulation in space differs

For example, according to a meta-analysis of randomised controlled trials, therapies with GLP-1 receptor agonists significantly reduced cardiovascular events and improved cardiometabolic parameters