For example, in order to maintain intracellular redox homeostasis and build a powerful antioxidant defense, cancer cells are typically characterized by high level of antioxidants, especially GSH with a high concentration of 10 mM, which is approximately ten times higher than that in normal cells ( In general, elevated GSH can be observed in many cancers, including lung cancer, ovarian cancer, breast cancer, and head-neck cancer, and this adaptive upregulation of GSH has various effects on tumor advancement, metastasis, and drug resistance (Wong et al., 2016)
Coronal sections (4 m thickness) were obtained using a rotary microtome and baked at 60C for 2 h to enhance tissue adhesion
doi: 10.3389/fgstr.2026.1802268 Received 02 February 2026 Revised 24 March 2026 Accepted 24 March 2026 Published 10 April 2026 Volume 5 - 2026 Edited by Ramars Amancy, Indian Institute of Chemical Technology (CSIR), India Reviewed by Faizan Ahmed, Cincinnati Childrens Hospital Medical Center, United States Zoofa Zayani, Nicolaus Copernicus University in Toru, Poland Updates Copyright 2026 Chooklin and Chuklin
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