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2 Initially approved for the treatment of advanced or unresectable melanoma, Keytruda received its 40th FDA indication approval on June 17, 2024, with the most recent approval covering endometrial cancer

for example, the greatest fold changes for alanine were observed among the most sensitive cells to MTX, whereas 2-oxoglutarate (-ketoglutarate) greatest fold changes were found among the most resistant cells to the antifolate ( Figure 1C )

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