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Ipamorelin is more selective than GHRP-2 or GHRP-6 - it stimulates GH release with minimal elevation of cortisol, prolactin, or ACTH

2 While it may alleviate some symptoms linked to hormonal decline, "anti-aging" is not a medically recognized indication, and large-scale research robustly supporting such effects in healthy aging adults requires more studies

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Our proposed receptor activation mechanism also suggests that the conformation of a GHSR ligand around the E124 3.33 -R283 6.55 salt bridge in the cavity II is an important structural determinant for ligand efficacy, providing a molecular foundation for designing novel ghrelin agonists