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The jump from one dose to the next brings a return of side effects similar to when you first started, though many people handle subsequent increases better with experience

The expanding role of GLP-1 receptor agonists: a narrative review of current evidence and future directions

Regulatory agencies are continuously updating guidelines for diabetes management, including recommendations regarding the use of GLP-1 agonists, which influence prescribing practices and market penetration

This is not true pharmacological tolerance in the classic sense, but rather the body finding a new equilibrium at the current level of receptor stimulation