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Wegovys higher maximum dose drives the higher rates seen below

At the expected therapeutic dose of 0.5mg, the discontinuation rate due to side effects was similar to that of the placebo group (32%).In another trial called TIPO-2, which lasted for 14 days, tesofensine was found to reduce the desire to eat and increase feelings of fullness in obese patients

It is important to understand that combining these medications would be considered off-label in the UK and would require specialist oversight within a formal weight management service

In the SOUL randomized clinical trial on oral semaglutide, for example, all participants taking semaglutide experienced clinically significant drops in blood pressure