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Abbreviations AUC: Area under the curve CNS: Central nervous system CCI: Chronic constriction injury cGMP: Cyclic guanosine monophosphate COX-2: Cyclooxygenase-2 CMC: Carboxymethyl cellulose DMSO: Dimethyl sulfoxide DRG: Dorsal root ganglion ELISA: Enzyme-linked immunosorbent assay ERK1/2: Extracellular signal-regulated kinase 1/2 GC: Guanylyl cyclase H&E: Hematoxylin and eosin IASP: International Association for the Study of Pain IL-6: Interleukin-6 i.pl.: Intraplantar I.P.: Intraperitoneal IV: Intravenous K ATP : ATP-sensitive potassium channel L-NAME: N-nitro-L-arginine methyl ester MAPK: Mitogen-activated protein kinase MB: Methylene blue MDA: Malondialdehyde nNOS: Neuronal nitric oxide synthase NO: Nitric oxide ODQ: 1H-oxadiazolo[3-a]quinoxalin-1-one PO: Per os (oral administration) PKG: Protein kinase G ROS: Reactive oxygen species s.c.: Subcutaneous TNF-: Tumor necrosis factor-alpha TRPV1: Transient receptor potential vanilloid 1 References St John Smith, E