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This review differentiates between low-dose methotrexate used in autoimmune diseases and high-dose methotrexate used in oncology, emphasizing mechanistic differences in hepatotoxicity pathways, integrating MASLD-related risk factors, and summarizing current non-invasive diagnostic strategies

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Important: If you experience any signs of a severe allergic reactionsuch as swelling of the lips, face, or tongue, difficulty breathing, wheezing, or widespread hivescall 911 or go to the nearest emergency department immediately

In case of dropout, an intention-to-treat approach was applied in order to prevent risk of bias as long as the assessed variable itself was available