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According to Stephan J Guyenet, PhD, who is a specialist in Obesity Neurobiology and creator of the Whole Health Source Web site, three causes of leptin resistance has been identified [32,33]: Inflammation: Inflammatory signaling in the hypothalamus is likely to be a significant cause of leptin resistance in animals and humans

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If youre eating foods with a lot of salt or carbohydrates, these may be increasing your water retention, as well