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While ARG is able to catabolize arginine into ornithine and polyamines to promote cell proliferation and tissue repair, NOS breaks down arginine into NO to be involved in immune response and inflammation regulation ( in vivo during pathogen infection through three distinct mechanisms: 1) Arg1 depletes L-arginine from DCs, thereby preventing NOS2 from generating NO, which is effective in defending the organism against pathogen infections

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It is recommended that diagnosis and genetic testing be done using a multidisciplinary approach, including genetic counseling to assist with family planning and provide the necessary psychosocial support