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Indirect linkages may exist: Though collagen does not influence oil production, the two can interact indirectly in the following ways: Improved skin hydration = balanced sebum, which includes collagen aids dermal water retention, well-hydrated skin may lead to less compensatory sebum production, and some people with dry skin generate more oil in reaction

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On the one hand, Akkermansia muciniphila enhances the junction strength between intestinal epithelial cells by regulating the expression of tight junction proteins, such as ZO-1, Occludin, and Claudin-1, to attempt to repair the disrupted intestinal barrier (Liu et al., 2023)

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Antibodies were directed against proteins implicated in key pathways such as apoptosis, cell cycle regulation, senescence, DNA repair/damage and oxidative stress

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