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Due to the increase in stress in the weight-bearing part of the joint, long-term strain will lead to cartilage exfoliation, hyperosteogeny, synovial hyperplasia, degeneration, etc

The convergence of multivariate, univariate, and network-based analyses further supports the robustness of these exploratory findings

12 and Supplementary Tables 315

In the case of chronic hyponatremia, treatment is variable: when sodium is 120129 mEq/L and the patient is mildly symptomatic or asymptomatic, it is sufficient to discontinue any drugs potentially causing hyponatremia, manage the underlying cause of low sodium, and limit oral or intravenous intake of water