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In addition to biocompatibility, biodegradation, bioadhesiveness, and biofunctionality of the NDBs, several drawbacks must be addressed, such as low stability, low melting point, high surface tension, structural complexity, and well-known immunological response from organisms (Ige et al., 2012

BPC-157 can be viewed in the context of fibroblast activity, angiogenesis and tissue responses in preclinical models, while the TB-500 / thymosin beta-4 in the context of the actin cytoskeleton, the monomeric actin pool, cell motility and the formation of vascular structures

Genes Dev 25(9):930945

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