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Antioxidants (vitamin C, E, CoQ10) lower oxidative stress in gametes and are great for elderly patients or patients with elevated oxidative markers

Food sources of B12 include animal products such as fish, meat, poultry, eggs, milk, and milk products

Oxidized ascorbate (monodehydroascorbate, MDA) can thereafter either spontaneously disproportionate to ascorbate and dehydroascorbate (DHA), or be reduced to ascorbate by the enzyme MDHAR, using the reducing power of NAD(P)H

Dieckman T, Schreurs M, Lindelauf C, Mahfouz A, Meijer CR, Pigeaud L, van Unen V, Bouma G, Koning F (2024) Activated CD27+PD-1+ CD8 T cells and CD4 T regulatory cells dominate the tumor microenvironment in refractory celiac disease type II