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They have an injury secondary to inflammation or something like that

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On a mechanistic level, the Psychedelic Iatrogenic Structural Dissociation (PISD) hypothesis proposes that these substances may lower the defensive barriers between the part of the personality that handles daily life (the Apparently Normal Personality) and the part that holds traumatic memories (the Emotional Personality), leading to psychological destabilization, emotional dysregulation, and identity fragmentation in individuals with histories of trauma [117,118,119]

In addition, IGF-1 LR3 may promote fat breakdown by activating the MAPK pathway, leading to increased levels of free fatty acids and further exacerbating insulin resistance, forming a vicious cycle