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Targeting NOS1 either through Hsp90 inhibitors to block its mitochondrial localization or via specific inhibitors such as N-propyl-L-arginine may offer dual benefits: mitigating therapy resistance and addressing metabolic risk factors in CRC (57, 58)

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The glucagon-like peptide-1 receptor (GLP-1R) is a class B1 G proteincoupled receptor and major therapeutic target in type 2 diabetes and obesity