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This reduction correlated with impaired motor function and the development of compulsive drug-seeking behaviors (Sekine et al., 2001)

In mice, knockout of ChREBP has been shown to reduce hepatic fatty acid synthesis by 65% compared to wild-type controls, but also to promote insulin resistance, delayed glucose clearance, and severe intolerance to simple carbohydrates, such as sucrose and fructose (resulting in death in the majority of animals) due to an inability to shunt fructose into glycolytic pathways [48]

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Lets explore how they work and why they might be worth considering as a solution