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Common Side Effects Most patients experience some nausea (usually mild, temporary, improves within 2-4 weeks), reduced appetite (this is therapeutic!), occasional digestive changes, and mild fatigue initially

These pathways provide a biological framework for interpreting microbiota changes during tirzepatide therapy

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Because semaglutide does not rely on these pathways, it has a relatively low potential for direct pharmacokinetic drug interactions with most commonly prescribed medications, as confirmed in the European Medicines Agency's European Public Assessment Report (EPAR)