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GLP-1-derived nonapeptide GLP-1(28-36) amide inhibits weight gain and attenuates diabetes and hepatic steatosis in diet-induced obese mice

Notwithstanding, previous studies have documented beneficial effects of the activation of estrogen receptors in diet-induced obese females, by reducing body weight and fat accumulation and improving leptin resistance at central level 53,54

However, active lipid metabolism occurs in lung tissues, especially within the alveolar area, where surfactant homeostasis is exquisitely regulated to ensure continuous optimal function in each respiration cycle