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These usually occur during the dose-escalation phase and tend to diminish over time. Patients can improve tolerability by consuming smaller portions and avoiding high-fat or spicy meals. Dosing should start low and be increased gradually based on tolerance and clinical goals. Administration and Storage Considerations Injectable agents such as dulaglutide and semaglutide must be refrigerated before the first use
B Complex supplements may also be recommended for certain groups of people
We monitor and dose-adjust to keep side effects manageable
In the LEADER trial evaluating liraglutide, patients experienced a mean heart rate increase of approximately 3 beats per minute compared to placebo over the study duration
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