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33-35 Although single studies evaluating the efficacy of metformin for treatment of hirsutism in patients with PCOS have shown potential benefits, 36-38 meta-analyses showed no significant effects of metformin compared to placebo or oral contraceptives and decreased benefits compared to spironolactone and flutamide

Unlike full-length GH, published laboratory research indicates this fragment does not appear to stimulate IGF-1 production or exhibit the same growth-promoting effects