dry mouth on glp 1 GLP-1 Receptor Signaling and Oral Dysfunction: A Narrative Review the Mechanistic Basis of Semaglutide-Related Oral Adverse Effects #ADAICYMI: What is “Ozempic Tongue”?

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Zou Y, Li H, Graham ET, Deik AA, Eaton JK, Wang W, et al

HRT and GLP-1: What Women Need to Know About Combining These Therapies At a glance Primary GLP-1 agents used with HRT / semaglutide 2.4 mg (Wegovy) and tirzepatide 15 mg (Zepbound) Mean weight loss with semaglutide 2.4 mg / 14.9% at 68 weeks in STEP-1 (N=1,961) Estrogen effect on visceral fat / transdermal 17-beta-estradiol reduces visceral adiposity by ~6-7% vs placebo per RCT data Oral estrogen risk with GLP-1 / slowed gastric emptying may reduce absorption