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In another study, researchers discovered that tirzepatide treatment, when combined with a decrease in circulating levels of branched-chain amino (BCAA) and keto (BCKA) acid metabolites linked to the development of systemic insulin resistance (IR) and T2DM improves insulin sensitivity in obese mice and humans with T2DM [82]

It has attracted significant research interest particularly in the context of obesity and metabolic disease and is widely regarded as one of the most promising compounds in contemporary cardiometabolic peptide research

This is approximately 4,167% of the daily recommended intake, which is intentionally high to compensate for reduced absorption during GLP-1 therapy