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FOXO4-DRI is among the highest-risk research peptides from an evidence-to-risk standpoint: it has never been tested in humans, no human pharmacokinetic data exists, and as a senolytic it carries theoretical risks specific to its mechanism

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When the researchers stratified the analysis according to treatment indication, the effect estimates were similar for people with asthma and overweight or obesity and for those with asthma and T2DM