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Prebiotics modulate the microbiota-gut-brain axis and ameliorate cognitive impairment in APP/PS1 mice

Recent molecular studies ascribed tamoxifen responses to the activation of the redox sensitive molecule NRF2, a transcription factor that regulates the expression of antioxidant proteins and promotes cell survival, with interesting implications for antineoplastic drug resistance mechanisms (Itoh et al., 1999

In contrast, the expression of GLP-1 mRNA in the colon tissues of mice in the model group decreased, and the content of GLP-1 in serum decreased

For instance, obesity is linked to increased inflammation and possibly a less healthy gut microbiome